解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Economically important reproduction traits in sheep, such as number of lambs weaned and litter size, are expressed only in females and later in life after most selection decisions are made, which makes them ideal candidates for genomic selection. Accurate genomic predictions would lead to greater genetic gain for thes...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12541
更新日期:2017-06-01 00:00:00
abstract::This review presents a broader approach to the implementation and study of runs of homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH and their practical implications. ROH are continuous homozygous segments that are common in individuals and populations. The ability of these homoz...
journal_title:Animal genetics
pub_type: 杂志文章,评审
doi:10.1111/age.12526
更新日期:2017-06-01 00:00:00
abstract::The aim of this study was to determine the allele frequency of the glycogen synthase 1 (GYS1) mutation associated with polysaccharide storage myopathy type 1 in the Austrian Noriker horse. Furthermore, we examined the influence of population substructures on the allele distribution. The study was based upon a comprehe...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12481
更新日期:2017-02-01 00:00:00
abstract::Fat-tailed sheep have commercial value because consumers prefer high-protein and low-fat food and producers care about feed conversion rate. However, fat-tailed sheep still have some scientific significance, as the fat tail is commonly regarded as a characteristic of environmental adaptability. Finding the candidate g...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12477
更新日期:2017-02-01 00:00:00
abstract::Protected designation of origin dry-cured hams are the most important productions of the Italian heavy pig industry. Hams capable of minimal seasoning losses produce better quality dry-cured hams. Ham weight loss during the first 7 days in brine (first salting) is highly correlated with the total loss of weight up to ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12491
更新日期:2017-02-01 00:00:00
abstract::Taste perception in animals affects feed intake and may influence production traits. In particular, bitter is sensed by receptors encoded by the family of TAS2R genes. In this research, using a DNA pool-seq approach coupled with next generation semiconductor based target resequencing, we analysed nine porcine TAS2R ge...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12472
更新日期:2017-02-01 00:00:00
abstract::Copy number variation (CNV), an essential form of genetic variation, has been increasingly recognized as one promising genetic marker in the analysis of animal genomes. Here, we used the Equine 70K single nucleotide polymorphism genotyping array for the genome-wide detection of CNVs in 96 horses from three diverse Chi...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12451
更新日期:2016-10-01 00:00:00
abstract::A pioneering study showed that the glycosphingolipid biosynthesis-globo series pathway genes (FUT1, FUT2, ST3GAL1, HEXA, HEXB, B3GALNT1 and NAGA) may play an important regulatory role in resistance to Escherichia coli F18 in piglets. Therefore, we analysed differential gene expression in 11 tissues of two populations ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12428
更新日期:2016-08-01 00:00:00
abstract::The stearoyl-CoA desaturase (delta-9-desaturase) gene encodes a key enzyme in the cellular biosynthesis of monounsaturated fatty acids. In our initial genome-wide association study (GWAS) of Chinese Holstein cows, 19 SNPs fell in a 1.8-Mb region (20.3-22.1 Mb) on chromosome 26 underlying the SCD gene and were highly s...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12432
更新日期:2016-08-01 00:00:00
abstract::The history of domestic sheep (Ovis aries) in Africa remains largely unknown. After being first introduced from the Near East, sheep gradually spread through the African continent with pastoral societies. The eastern part of Africa was important either for the first diffusion of sheep southward or for putative seconda...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12412
更新日期:2016-06-01 00:00:00
abstract::Drip loss, one of the most important meat quality traits, is characterized by low heritability. To date, the genetic factors affecting the drip loss trait have not been clearly elucidated. The objective of this study was to identify critical candidate genes affecting drip loss. First, we generated a Pietrain × Duroc ×...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12401
更新日期:2016-04-01 00:00:00
abstract::Africa is host to diverse and locally adapted cattle breeds that are expected to survive the harsh and extreme tropical environments associated with diseases and parasite infections, heat stress and episodes of feed and water scarcity. Genomic copy number variations (CNVs) are considered to be primary role players in ...
journal_title:Animal genetics
pub_type: 杂志文章,评审
doi:10.1111/age.12391
更新日期:2016-04-01 00:00:00
abstract::With the recent development of whole-exome sequencing enrichment designs for the dog, a novel tool for disease-association studies became available. The aim of disease-association studies is to identify one or a very limited number of putative causal variants or genes from the large pool of genetic variation. To maxim...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12400
更新日期:2016-04-01 00:00:00
abstract::In this study, we investigated at the genome-wide level if 20 years of artificial directional selection based on boar genetic evaluation obtained with a classical BLUP animal model shaped the genome of the Italian Large White pig breed. The most influential boars of this breed (n = 192), born from 1992 (the beginning ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12392
更新日期:2016-04-01 00:00:00
abstract::Cholesterol deficiency, a new autosomal recessive inherited genetic defect in Holstein cattle, has been recently reported to have an influence on the rearing success of calves. The affected animals show unresponsive diarrhea accompanied by hypocholesterolemia and usually die within the first weeks or months of life. H...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12410
更新日期:2016-04-01 00:00:00
abstract::An important aim in animal breeding is the improvement of growth and meat quality traits. Previous studies have demonstrated that genetic variants in the fat mass and obesity associated (FTO) gene have a relatively large effect on human obesity as well as on body composition in rodents and, more recently, in livestock...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12403
更新日期:2016-04-01 00:00:00
abstract::A novel gene that was predicted to encode a long noncoding RNA (lncRNA) transcript was identified in a previous study that aimed to detect candidate genes related to growth rate differences between Chinese local breed Gushi chickens and Anka broilers. To characterise the biological function of the lncRNA, we cloned an...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12387
更新日期:2016-02-01 00:00:00
abstract::A feral donkey population (Equus asinus), living in the Asinara National Park (an island north-west of Sardinia, Italy), includes a unique white albino donkey subpopulation or colour morph that is a major attraction of this park. Disrupting mutations in the tyrosinase (TYR) gene are known to cause recessive albinisms ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12386
更新日期:2016-02-01 00:00:00
abstract::Local breeds of livestock are of conservation significance as components of global biodiversity and as reservoirs of genetic variation relevant to the future sustainability of agriculture. One such rare historic breed, the Chillingham cattle of northern England, has a 350-year history of isolation and inbreeding yet s...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12376
更新日期:2016-02-01 00:00:00
abstract::Genomic selection is becoming a standard tool in livestock breeding programs, particularly for traits that are hard to measure. Accuracy of genomic selection can be improved by increasing the quantity and quality of data and potentially by improving analytical methods. Adding genotypes and phenotypes from additional b...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12362
更新日期:2016-02-01 00:00:00
abstract::A candidate gene analysis of the microphthalmia-associated transcription factor (MITF) gene was used in an attempt to identify the genetic basis for a white-spotted coat color phenotype in the Asian swamp buffalo (Bubalus bubalis carabanensis). Ninety-three buffaloes-32 solid, 38 spotted and 23 white individuals-were ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12334
更新日期:2015-12-01 00:00:00
abstract::Ligneous membranitis (LM) is a rare chronic inflammatory condition of the mucous membranes associated with plasminogen (encoded by PLG) deficiency in affected humans and dogs. In human, the condition is genetic in nature with numerous mutations and polymorphisms in PLG identified in affected individuals and related fa...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12339
更新日期:2015-12-01 00:00:00
abstract::The silkworm, Bombyx mori, is an economically important insect that was domesticated more than 5000 years ago. Its major economic traits focused on by breeders are quantitative traits, and an accurate and efficient QTL mapping method is necessary to explore their genetic architecture. However, current widely used QTL ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12311
更新日期:2015-08-01 00:00:00
abstract::Genotype imputation facilitates the identification of missing genotypes on a high-density array using low-density arrays and has great potential for reducing genotyping costs for cattle populations. However, the imputation quality varies across breeds, which have different effective population sizes. Therefore, the ac...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12314
更新日期:2015-08-01 00:00:00
abstract::The myxovirus resistance (Mx) proteins belong to the dynamin superfamily and are important for innate host defence against RNA viruses. In this study, we demonstrate that positive elements are present in the two promoter regions of -2713 to -2565 and -688 to -431 in the porcine MX1 gene. Sequencing and alignment of th...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12316
更新日期:2015-08-01 00:00:00
abstract::In this study, we have characterized the mitochondrial diversity of 81 swine from Uganda. Median-joining network analysis of D-loop sequences from these individuals and others characterized in previous studies allowed us to determine that Ugandan pigs cluster with populations from the West (Europe/North Africa), Far E...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12305
更新日期:2015-08-01 00:00:00
abstract::The induction of triploidization in fish is a very common practice in aquaculture. Although triploidization has been applied successfully in many salmonid species, little is known about the epigenetic mechanisms implicated in the maintenance of the normal functions of the new polyploid genome. By means of methylation-...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12287
更新日期:2015-06-01 00:00:00
abstract::There are two categories of immune responses - innate and adaptive immunity - both having polygenic backgrounds and a significant environmental component. In our study, adaptive immunity was represented by the specific antibody response toward keyhole limpet hemocyanin (KLH); innate immunity was represented by natural...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12280
更新日期:2015-06-01 00:00:00
abstract::Abdominal fat content is an economically important trait in commercially bred chickens. Although many quantitative trait loci (QTL) related to fat deposition have been detected, the resolution for these regions is low and functional variants are still unknown. The current study was conducted aiming at increasing resol...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12263
更新日期:2015-04-01 00:00:00
abstract::Modern commercial chickens have been bred for one of two specific purposes: meat production (broilers) or egg production (layers). This has led to large phenotypic changes, so that the genomic signatures of selection may be detectable using statistical techniques. Genetic differentiation between nine distinct broiler ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12252
更新日期:2015-02-01 00:00:00
abstract::Donkey domestication drastically changed ancient transport systems in Africa and Asia, enabling overland circulation of people and goods and influencing the organization of early cities and pastoral societies. Genetic studies based on mtDNA have pointed to the African wild ass as the most probable ancestor of the dome...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12256
更新日期:2015-02-01 00:00:00
abstract::Performance data for 164,046 Thoroughbreds entered in a race or official barrier trial in Australia were provided by Racing Information Services Australia. Analyses estimating the heritability for a range of racing performance traits using a single-trait animal model were performed using ASREML-R. Log of cumulative ea...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12234
更新日期:2015-02-01 00:00:00
abstract::Positive selection not only increases beneficial allele frequency but also causes augmentation of allele frequencies of sequence variants in close proximity. Signals for positive selection were detected by the statistical differences in subsequent allele frequencies. To identify selection signatures in Korean cattle, ...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12209
更新日期:2014-12-01 00:00:00
abstract::MicroRNA (miRNA) biogenesis is determined mainly by Drosha, Dicer and Argonaute2 (Ago2). Different breeds of pigs with vast differences in serum cortisol level demonstrate distinct profiles of hepatic miRNA expression. As yet, little is known about whether glucocorticoid contributes to the breed differences in miRNA b...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12232
更新日期:2014-12-01 00:00:00
abstract::Supernumerary teats represent a common abnormality of the bovine udder. A genome-wide association study was performed based on the proportion of the occurrence of supernumerary teats in the daughters of 1097 Holstein bulls. The heritability of caudal supernumerary teats without mammary gland in this study was 0.604. T...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12215
更新日期:2014-12-01 00:00:00
abstract::The extent of linkage disequilibrium (LD) between genetic loci has implications for both association studies and the accuracy of genomic prediction. To characterise the persistence of LD in diverse sheep breeds, two SNP genotyping platforms were used. First, existing SNP genotypes from 63 breeds obtained using the ovi...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12197
更新日期:2014-10-01 00:00:00
abstract::Understanding the genetic basis of variation in traits related to growth and fillet quality in Atlantic salmon is of importance to the aquaculture industry. Several growth-related QTL have been identified via the application of genetic markers. The IGF1 gene is considered a highly conserved and crucial growth-regulati...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12202
更新日期:2014-10-01 00:00:00
abstract::To understand the origin and genetic diversity of Italian horses, mitochondrial DNA D-loop sequences were generated for 163 horses from seven breeds. Sequence analysis of a 480-bp segment revealed a total of 84 haplotypes with 57 polymorphic sites, indicating multiple maternal origins and high genetic diversity. Compa...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12156
更新日期:2014-08-01 00:00:00
abstract::Colostrum intake is critical to a piglet's survival and can be measured by precipitating out the γ-immunoglobulins from serum with ammonium sulfate (immunocrit). Genetic analysis of immunocrits on 5312 piglets indicated that the heritabilities (se) for direct and maternal effects were 0.13 (0.06) and 0.53 (0.08) respe...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12131
更新日期:2014-06-01 00:00:00
abstract::KIT mutations have been detected in different cancer subtypes, including melanoma. The gene also has been extensively studied in farm animals for its prominent role in coat color. The present work aimed at detecting KIT variants in a porcine model of cutaneous melanoma, the melanoblastoma-bearing Libechov Minipig (MeL...
journal_title:Animal genetics
pub_type: 杂志文章
doi:10.1111/age.12136
更新日期:2014-06-01 00:00:00